The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

Cancer Cell International

Ren Zhao¹  Yan-Yang Wang¹  Guang-Fei Yang²  Yi-Ge Su³  Xin Zhang⁴ 

[1] Dept. of Radiation Oncology, General Hospital of Ningxia Medical University, 750004, Yinchuan, Ningxia, China;Cancer Institute, Ningxia Medical University, 750004, Yinchuan, Ningxia, China;Dept. of Ultrasound, General Hospital of Ningxia Medical University, 750004, Yinchuan, Ningxia, China;Graduate School, Ningxia Medical University, 750004, Yinchuan, Ningxia, China;School of Clinical Medicine, Ningxia Medical University, 750004, Yinchuan, Ningxia, China;

关键词: DUB3USP17;    Cancer;    Ubiquitination;    Deubiquitinating enzymes;    Signaling pathways;   

DOI  :  10.1186/s12935-021-02160-y

来源: Springer

【 摘 要 】

The balance between ubiquitination and deubiquitination is critical for the degradation, transport, localization, and activity of proteins. Deubiquitinating enzymes (DUBs) greatly contribute to the balance of ubiquitination and deubiquitination, and they have been widely studied due to their fundamental role in cancer. DUB3/ubiquitin-specific protease 17 (USP17) is a type of DUB that has attracted much attention in cancer research. In this review, we summarize the biological functions and regulatory mechanisms of USP17 in central nervous system, head and neck, thoracic, breast, gastrointestinal, genitourinary, and gynecologic cancers as well as bone and soft tissue sarcomas, and we provide new insights into how USP17 can be used in the management of cancer.

【 授权许可】

CC BY