The COP9 signalosome subunit 6 (CSN6): a potential oncogene

Cell Division

Jun-Nian Zheng²  Dong-Sheng Pei¹  Shang-Nuan Zhang¹ 

[1] Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou, Jiangsu, P.R. China;Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China

关键词: Deneddylation;    Ubiquitination;    Cancer;    CSN6;    CSN;   

Others  :  790394
DOI  :  10.1186/1747-1028-8-14

 received in 2013-10-17, accepted in 2013-11-18,  发布年份 2013

【 摘 要 】

CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repressor of light-dependent growth and transcription in Arabidopsis. CSN is homologous to the 19S lid subcomplex of the 26S proteasome, thus it has been postulated to be a regulator of the ubiquitin-proteasome pathway. In mammalian cells, it consists of eight subunits (CSN1-CSN8). Among the CSN subunits, CSN5 and CSN6 are the only two that each contains an MPN (Mpr1p and Pad1p N-terminal) domain. The deneddylating activity of an MPN domain toward cullin-RING ubiquitin ligases (CRL) may coordinate CRL-mediated ubiquitination activity. More and more studies about CSN6 are emerging, and its overexpression is found in many types of cancers. Evidence has shown that CSN6 is a molecule platform between protein degradation and signal transduction. Here, we provide a summary of human CSN6, especially its roles in cancer, hoping that it can lay the groundwork for cancer prevention or therapy.

【 授权许可】

   
2013 Zhang et al.; licensee BioMed Central Ltd.

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