Protective role of nitric oxide donors on endothelium in ischemia-reperfusion injury: a meta-analysis of randomized controlled trials

BMC Anesthesiology

Research

Xue Han¹  Xinmin Zhang²  Xue Xiao³  Weifeng Yao³  Ziyan Huang³  Chaoxun Dou³  Hanbin Xie³  Haofeng Liao³  Gangjian Luo³ 

[1] Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, Guangzhou, China;Department of Anesthesiology, The First Hospital of Jilin University, 130021, Changchun, China;Department of Anesthesiology, The third Affiliated hospital of Sun Yat-sen University, 510630, Guangzhou, China;

关键词: Nitric oxide donors;    Ischemia reperfusion;    Endothelium;    Flow-meditate dilation;    Meta-analysis;   

DOI  :  10.1186/s12871-023-02117-w

 received in 2022-10-23, accepted in 2023-04-29,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDecreased bioavailability of nitric oxide (NO) under hypoxic conditions can lead to endothelial dysfunction. NO supplementation may protect endothelial function in ischemia-reperfusion (IR) injury. Therefore, a meta-analysis of randomized controlled trials (RCTs) was performed to verify the protective effect of NO donors on endothelium in IR injury.MethodsMedline, Embase, Cochrane Library, and Web of Science databases were searched from inception to April 1, 2023. The specific inclusion criteria were as follows: (1) RCTs; (2) trials comparing NO donors with placebo control groups; and (3) trials reporting the effects of these interventions on vascular endothelial functional outcomes in IR injury. Random-effects models were used to assess pooled effect sizes, which were expressed as standardized mean differences (SMD).ResultsSeven studies satisfied the inclusion criteria and consisted of a total of 149 participants. NO donors were protective of endothelial function in IR injury (SMD: − 1.60; 95% confidence interval [CI]: − 2.33, − 0.88, P < 0.0001; heterogeneity [I2 = 66%, P = 0.001]). Results of the subgroup analysis showed the following: absence of protective effect of NO donor use following ischemia on endothelial function in IR injury − 1.78 (95% CI: − 2.50, − 1.07) and loss of protective effect on endothelial function after prolonged NO donor use − 0.89 (95% CI: − 2.06, 0.28).ConclusionThe short-period use of NO donors before the onset of ischemia can protect endothelial function in IR injury.

【 授权许可】

CC BY   
© The Author(s) 2023

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