Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes

BMC Microbiology

Research

Ru Yang¹  Wentao Peng¹  Bairong Shen²  Xiaoyu Li²  Yinan Wang³  Qingyu Wang⁴  Zicheng Zhao⁵  Zhiye Ying⁶ 

[1] Department of Neonatology Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China;Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Sichuan, China;Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, China;School of Business Administration, Northeast University, Shenyang, China;Shenzhen Byoryn Technology, Shenzhen, Guangdong, P.R. China;West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China;Medical Big Data Center, Sichuan University, Chengdu, Sichuan, China;

关键词: Preterm birth;    Gastrointestinal microbiota;    Shotgun metagenomics sequencing;    Lachnospiraceae;    Short-chain fatty acids;    Interleukin- 1;   

DOI  :  10.1186/s12866-023-02892-z

 received in 2022-12-31, accepted in 2023-05-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPreterm birth is the leading cause of perinatal morbidity and mortality. Despite evidence shows that imbalances in the maternal microbiome associates to the risk of preterm birth, the mechanisms underlying the association between a perturbed microbiota and preterm birth remain poorly understood.MethodApplying shotgun metagenomic analysis on 80 gut microbiotas of 43 mothers, we analyzed the taxonomic composition and metabolic function in gut microbial communities between preterm and term mothers.ResultsGut microbiome of mothers delivering prematurely showed decreased alpha diversity and underwent significant reorganization, especially during pregnancy. SFCA-producing microbiomes, particularly species of Lachnospiraceae, Ruminococcaceae, and Eubacteriaceae, were significantly depleted in preterm mothers. Lachnospiraceae and its species were the main bacteria contributing to species’ differences and metabolic pathways.ConclusionGut microbiome of mothers delivering prematurely has altered and demonstrates the reduction of Lachnospiraceae.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 4

Fig. 2

Fig. 1

41116_2023_37_Article_IEq161.gif