Trends in cognitive function before and after stroke in China

BMC Medicine

Research Article

Yueping Shen¹  Jianian Hua²  Jianye Dong³  Guo-Chong Chen⁴ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Ren’ai Road, 215123, Suzhou, China;Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Ren’ai Road, 215123, Suzhou, China;Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Ren’ai Road, 215123, Suzhou, China;Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Nutrition and Food Hygiene, Suzhou Medical College of Soochow University, 199 Ren’ai Road, 215123, Suzhou, China;

关键词: Stroke;    Cognitive function;    Chinese population;    Cohort study;   

DOI  :  10.1186/s12916-023-02908-5

 received in 2023-01-31, accepted in 2023-05-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundWhile cognitive impairment after stroke is common, cognitive trends before stroke are poorly understood, especially among the Chinese population who have a relatively high stroke burden. We aimed to model the trajectories of cognitive function before and after new-onset stroke among Chinese.MethodsA total of 13,311 Chinese participants aged ≥ 45 years and without a history of stroke were assessed at baseline between June 2011 and March 2012 and in at least one cognitive test between 2013 (wave 2) and 2018 (wave 4). Cognitive function was assessed using a global cognition score, which included episodic memory, visuospatial abilities, and a 10-item Telephone Interview of Cognitive Status (TICS-10) test to reflect calculation, attention, and orientation abilities.ResultsDuring the 7-year follow-up, 610 (4.6%) participants experienced a first stroke. Both stroke and non-stroke groups showed declined cognitive function during follow-up. After adjustment for covariates, there was no significant difference in pre-stroke cognitive trajectories between stroke patients and stroke-free participants. The stroke group showed an acute decline in episodic memory (− 0.123 SD), visuospatial abilities (− 0.169 SD), and global cognition (− 0.135 SD) after stroke onset. In the years following stroke, the decline rate of the TICS-10 test was higher than the rate before stroke (− 0.045 SD/year).ConclusionsChinese stroke patients had not experienced steeper declines in cognition before stroke compared with stroke-free individuals. Incident stroke was associated with acute declines in global cognition, episodic memory, visuospatial abilities, and accelerated declines in calculation, attention, and orientation abilities.

【 授权许可】

CC BY   
© The Author(s) 2023

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