Associations between post-stroke motor and cognitive function: a cross-sectional study

BMC Geriatrics

Hege Ihle-Hansen¹  Anne-Brita Knapskog¹  Ragnhild Munthe-Kaas²  Marie H. Ursin²  Stian Lydersen³  Halvor Næss⁴  Pernille Thingstad⁵  Marte Stine Einstad⁵  Torunn Askim⁵  Ingvild Saltvedt⁶  Hanne Ellekjær⁷  Mona K. Beyer⁸  Yngve M. Seljeseth⁹ 

[1] Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway;Department of Medicine, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway;Department of Mental Health, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway;Department of Neurology, Haukeland University Hospital, Bergen, Norway;Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway;Institute of Clinical Medicine, University of Bergen, Bergen, Norway;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway;Department of Geriatric Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway;Stroke Unit, Department of Internal Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway;Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway;Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Medical Department, Ålesund Hospital, Møre and Romsdal Health Trust, Ålesund, Norway;

关键词: Stroke;    Cognitive function;    Motor function;    Function;   

DOI  :  10.1186/s12877-021-02055-7

来源: Springer

【 摘 要 】

BackgroundMotor and cognitive impairments are frequently observed following stroke, but are often managed as distinct entities, and there is little evidence regarding how they are related. The aim of this study was to describe the prevalence of concurrent motor and cognitive impairments 3 months after stroke and to examine how motor performance was associated with memory, executive function and global cognition.MethodsThe Norwegian Cognitive Impairment After Stroke (Nor-COAST) study is a prospective multicentre cohort study including patients hospitalized with acute stroke between May 2015 and March 2017. The National Institutes of Health Stroke Scale (NIHSS) was used to measure stroke severity at admission. Level of disability was assessed by the Modified Rankin Scale (mRS). Motor and cognitive functions were assessed 3 months post-stroke using the Montreal Cognitive Assessment (MoCA), Trail Making Test Part B (TMT-B), 10-Word List Recall (10WLR), Short Physical Performance Battery (SPPB), dual-task cost (DTC) and grip strength (Jamar®). Cut-offs were set according to current recommendations. Associations were examined using linear regression with cognitive tests as dependent variables and motor domains as covariates, adjusted for age, sex, education and stroke severity.ResultsOf 567 participants included, 242 (43%) were women, mean (SD) age was 72.2 (11.7) years, 416 (75%) had an NIHSS score ≤ 4 and 475 (84%) had an mRS score of ≤2. Prevalence of concurrent motor and cognitive impairment ranged from 9.5% for DTC and 10WLR to 22.9% for grip strength and TMT-B. SPPB was associated with MoCA (regression coefficient B = 0.465, 95%CI [0.352, 0.578]), TMT-B (B = -9.494, 95%CI [− 11.726, − 7.925]) and 10WLR (B = 0.132, 95%CI [0.054, 0.211]). Grip strength was associated with MoCA (B = 0.075, 95%CI [0.039, 0.112]), TMT-B (B = -1.972, 95%CI [− 2.672, − 1.272]) and 10WLR (B = 0.041, 95%CI [0.016, 0.066]). Higher DTC was associated with more time needed to complete TMT-B (B = 0.475, 95%CI [0.075, 0.875]) but not with MoCA or 10WLR.ConclusionThree months after suffering mainly minor strokes, 30–40% of participants had motor or cognitive impairments, while 20% had concurrent impairments. Motor performance was associated with memory, executive function and global cognition. The identification of concurrent impairments could be relevant for preventing functional decline.Trial registrationClinicalTrials.gov Identifier: NCT02650531.

【 授权许可】

CC BY