The updates and implications of cutaneous microbiota in acne

Cell & Bioscience

Review

Kaoyuan Zhang¹  Zhenzhen Chen²  Xingling Jian²  Haiyan Huang²  Fan Zhuo²  Wenting Li²  Xia Dou²  Cong Huang²  Bin Jiang²  Hui Li²  Bo Yu²  Baoquan Han³ 

[1] Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, 518036, Shenzhen, China;Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Translational Medicine of Dermatology, Peking University Shenzhen Hospital, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, 518036, Shenzhen, China;Department of Urology, Shenzhen University General Hospital, 518055, Shenzhen, China;

关键词: Acne;    Cutaneous microbiota;    Pathogenesis;    Probiotics;   

DOI  :  10.1186/s13578-023-01072-w

 received in 2023-03-27, accepted in 2023-06-13,  发布年份 2023

来源: Springer

【 摘 要 】

Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age groups. Acne pathogenesis is believed to be a result of various endogenous and exogenous factors, but the precise mechanisms remain elusive. Recent studies suggest that dysbiosis of the skin microbiota significantly contributes to acne development. Specifically, Cutibacterium acnes, the dominant resident bacterial species implicated in acne, plays a critical role in disease progression. Various treatments, including topical benzoyl peroxide, systemic antibiotics, and photodynamic therapy, have demonstrated beneficial effects on the skin microbiota composition in acne patients. Of particular interest is the therapeutic potential of probiotics in acne, given its direct influence on the skin microbiota. This review summarizes the alterations in skin microbiota associated with acne, provides insight into its pathogenic role in acne, and emphasizes the potential of therapeutic interventions aimed at restoring microbial homeostasis for acne management.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 2