Pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis

BMC Oral Health

Research

Marco Antonio Rimachi Hidalgo¹  Raquel Mantuaneli Scarel-Caminaga¹  Roberta de Oliveira Alves²  Suzane Cristina Pigossi²  Isabella Mazarelo Nascimento³  Jovânia Alves Oliveira³ 

[1] Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara, (FOAr/UNESP), UNESP- São Paulo State University, Araraquara, São Paulo, Brazil;Department of Periodontology, School of Dentistry, School of Dentistry, Federal University of Uberlândia - UFU, Umuarama Campus, Bloco UMU4L, Pará Avenue, 1720, 38405-320, Uberlândia, Minas Gerais, Brazil;School of Dentistry, Alfenas Federal University (Unifal-MG), Alfenas, Minas Gerais, Brazil;

关键词: Peri-implantitis;    Cytokines;    Bone resorption;    Dental implants;   

DOI  :  10.1186/s12903-023-03072-1

 received in 2023-01-07, accepted in 2023-05-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPro- and anti-inflammatory cytokines are acknowledged, during inflammatory bone destruction, as key regulators of osteoclast and osteoblast differentiation and activity. However, evidence regarding the exact role of pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases is unclear. We aimed to execute a systematic review and meta-analysis about the pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors levels in peri-implant diseases.MethodsThe focused question was elaborated to summarize the levels of pro-and anti-inflammatory cytokines and osteoclastogenesis-related factors in tissue samples (mRNA) and biofluids (protein levels) of patients with/without peri-implant diseases. Electronic searches of the PubMed, Cochrane Controlled Trials Registry, Web of Science, EMBASE, Scopus and Google scholar databases were conducted for publications up to March 2023. Meta-analysis evaluating the mediator´s levels (protein levels by ELISA) in peri-implant crevicular fluid (PICF) were made. The effect size was estimated and reported as the mean difference. The 95% confidence interval was estimated for each mediator, and the pooled effect was determined significant if two-sided p-values < 0.05 were obtained.ResultsTwenty-two publications were included in the systematic review (qualitative analysis), with nine of these subjected to meta-analyses (quantitative analysis). In the qualitative analysis, higher pro-inflammatory cytokines [Interleukin (IL)-1β, IL-6] and pro-osteoclastogenic mediator [Receptor Activator of Nuclear Factor-Kappa B ligand (RANKL)] levels were observed in PICF of individuals with peri-implant diseases in comparison to healthy individuals. Higher RANKL/osteoprotegerin (OPG) ratios were observed in PICF from individuals with peri-implant diseases in comparison to healthy individuals. Meta-analysis showed higher RANKL levels in diseased groups compared to controls.ConclusionsThe results showed that the levels of IL-1β, IL-6, IL-10, and RANKL/OPG are not balanced in peri-implant disease, suggesting that these mediators are involved in the host osteo-immunoinflammatory response related to peri-implantitis.

【 授权许可】

CC BY   
© The Author(s) 2023

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