The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer

BMC Gastroenterology

Research

Yingyong Hou¹  Weixia Wang²  Dacheng Bu²  Jing Liu²  Meihong Cheng²  Junxia Yao²  Jican Liu²  Hongyan Jing²  Yanchao Xu²  Ting Zhu²  Kui Lu²  Qilin Zhai² 

[1] Department of Pathology, Zhongshan Hospital, Fudan University, 201700, Shanghai, P.R. China;Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 East Park Road, Qingpu District, 200032, Shanghai, P.R. China;

关键词: CD4 + T cell;    CD8 + T cell;    C-reactive protein;    Schistosomiasi;    Colorectal cancer;    Prognosis;   

DOI  :  10.1186/s12876-023-02834-z

 received in 2022-08-13, accepted in 2023-05-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAlthough schistosomiasis has been basically eliminated, it has not been completely extinction in China and occasional outbreaks occur in Europe in recent years. The relationship between inflammation caused by Schistosoma japonicum and colorectal cancer (CRC) is still obscure, and the inflammation based prognostic systems of schistosomal colorectal (SCRC) has rarely been reported.AimTo explore the different roles of tumor infiltrating lymphocytes (TILs) and C-reactive protein (CRP) in SCRC and in Non-schistosomal CRC (NSCRC), providing a possible predictive system to evaluate outcomes and to improve the risk stratification for CRC patients, especially for CRC patients with schistosomiasis.MethodsThree hundred fifty-one CRC tumors were evaluated for density of CD4 + , CD8 + T cells and CRP in intratumoral and stromal compartments by immunohistochemical using tissue microarray.ResultsThere were no association between TILs and CRP and schistosomiasis. Multivariate analysis identified stromal CD4 (sCD4) (p = 0.038), intratumoral CD8 (iCD8) (p = 0.003), schistosomiasis (p = 0.045) as independent prognostic factors for overall survival (OS) in the whole cohort; and sCD4 (p = 0.006) and iCD8 (p = 0.020) were independent prognostic factors for OS in the NSCRC and SCRC set, respectively. Besides, we found that there were no differences of TILs and CRP, which were distributed in different areas of tumor tissue, between CRC patients with and without schistosomiasis.ConclusionThe results remind us that different subtypes of TILs have distinguished biological behavior and prognosis value in the immune microenvironment of NSCRC and SCRC patients. Meanwhile, the findings require us to stratify patients with schistosomiasis and this might facilitate patient counseling and management.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2023_37_Article_IEq4.gif

Fig. 2

Fig. 1

Fig. 1