Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis

Child and Adolescent Psychiatry and Mental Health

Research

Joo-Hyun Kim¹  Guiyoung Bong¹  Jae Hyun Han¹  Ye Rim Kim²  Hee Jeong Yoo²  Da-Yea Song³ 

[1] Department of Psychiatry, Seoul National University Bundang Hospital, 82 Gumi-Ro 173Beon-Gil, Bundang-Gu, 13620, Seongnam, Republic of Korea;Department of Psychiatry, Seoul National University Bundang Hospital, 82 Gumi-Ro 173Beon-Gil, Bundang-Gu, 13620, Seongnam, Republic of Korea;Department of Psychiatry, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea;Department of Psychiatry, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea;

关键词: Autism spectrum disorder;    Tic disorder;    Yale Global Tic Severity Scale;    Intelligence Quotient;    Comorbidity;   

DOI  :  10.1186/s13034-023-00625-8

 received in 2023-03-07, accepted in 2023-06-02,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe frequency, clinical characteristics, and associated symptoms of comorbid tic disorders in individuals with autism spectrum disorder (ASD) remain unclear.MethodsWe included subsets of individuals from a larger genetic study who were diagnosed with ASD (n = 679; age: 4–18 years) and completed the Yale Global Tic Severity Scale (YGTSS) questionnaire. Based on the YGTSS score, the individuals were divided into two groups: ASD only (n = 554) and ASD with tics (n = 125). Individuals were assessed using the verbal and non-verbal intelligence quotient (IQ), Vineland Adaptive Behavior Scale (VABS-2), Social Responsiveness Scale-2 (SRS-2), Child Behavior Checklists (CBCL), and Yale-Brown Obsessive–Compulsive Scale (YBOCS), followed by between-group comparisons. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) version 26.ResultsTic symptoms were observed in 125 (18.4%) participants; among them, most participants presented both motor and vocal tics (n = 40, 40.0%). The ASD with tics group had a significantly higher average age and full-scale IQ score than the ASD only group. After adjusting for age, the ASD with tics group had significantly higher scores in the SRS-2, CBCL, and YBOCS subdomains than the ASD only group. Furthermore, all variables except the non-verbal IQ and VABS-2 scores were positively correlated with the YGTSS total score. Finally, the proportion of tic symptoms was significantly higher among individuals with a higher IQ score (≥ 70).ConclusionsThe IQ score was positively correlated with the proportion of tic symptoms among individuals with ASD. Moreover, the severity of the core and comorbid symptoms of ASD was associated with the occurrence and severity of tic disorders. Our findings suggest the need for appropriate clinical interventions for individuals with ASD.Trial registration This study retrospectively registered participants

【 授权许可】

CC BY   
© The Author(s) 2023

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