Differential correlation between time in range and eGFR or albuminuria in type 2 diabetes

Diabetology & Metabolic Syndrome

Research

Hui Zhou¹  Zhen Zhang¹  Yanyu Yuan²  Wenwen Jiang²  Yong Zhong³  Xinyi Yang³  Chunyan Liu³  Jiaqing Shao³  Zhouqin Feng³  Ping Gu³  Yue Liang³  Qingyu Guo³  Jingjing Liang³  Yixin Xu³  Bin Lu³  Xuguang Jin³  Wei Wang³ 

[1]Department of Endocrinology, Jinling Hospital, First School of Clinical Medicine, Southern Medical University, Nanjing, China

[2]Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

[3]Medical School, Affiliated Jinling Hospital, Department of Endocrinology, Nanjing University, 305 East Zhongshan Road, 210002, Nanjing, Jiangsu, China

关键词: Albuminuria;    Hypoglycemia;    Glomerular filtration rate;    Time in range;    Nocturnal time in range;    Continuous glucose monitoring;    Hemoglobin A1C;    Type 2 diabetes mellitus;   

DOI  :  10.1186/s13098-023-01071-4

 received in 2023-04-11, accepted in 2023-04-27,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionAs a CGM-derived indicator, ‘time in range’ (TIR) is emerging as a key indicator for accurate assessment of glycaemic control. However, there is few report focusing on the correlation of TIR with albumuria and renal fuction. The aim of this work was to investigate whether TIR, as well as nocturnal TIR and hypoglycaemic events is related to the presence and severity of albuminuria and decrease of eGFR in type 2 diabetes.Research design and methodsA total of 823 patients were enrolled in this study. All patients received continuous glucose monitoring, TIR indicating the percentage of time that blood glucose was in the range of 3.9–10.0 mmol/L. The Spearman analysis was applied to analyze the relationship between TIR (or nocturnal TIR) and ACR. Logistic regression was used to explore whether TIR (or nocturnal TIR) is an independent risk factor for albuminuria.ResultsThe prevalence of albuminuria decreased with increasing TIR quartiles. Binary logistic regression revealed that TIR as well as nocturnal TIR was obviously related to the presence of albuminuria. Multiple regression analysis found that only nocturnal TIR was obviously related to the severity of albuminuria. In our study, eGFR was significantly associated with the number of hypoglycemic events.ConclusionsIn T2DM patients, TIR and nocturnal TIR is associated with the presence of albuminuria independent of HbA1c and GV metrics. Nocturnal TIR shows better correlation than TIR. The role of TIR especially nocturnal TIR in the evaluation of diabetes kidney disease should be emphasized.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 6