The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: protocol for a randomised controlled crossover trial

BMC Musculoskeletal Disorders

Study Protocol

Charlotte V. Coombs¹  Thomas J. O’Leary¹  Julie P. Greeves¹  Sophie L. Wardle¹  Anton Eisenhauer²  William D. Fraser³  Jonathan C. Y. Tang³  Rukshana Shroff⁴ 

[1]Army Health and Performance Research, Army Headquarters, SP11 8HT, Andover, UK

[2]GEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany

[3]Norwich Medical School, University of East Anglia, Norwich, UK

[4]Renal Unit, UCL Great Ormond Street Hospital for Children NHS Foundation Trust and Institute of Child Health, London, UK

关键词: Bone metabolism;    Calcium;    Supplement;    Exercise;    Load carriage;   

DOI  :  10.1186/s12891-023-06600-w

 received in 2023-02-17, accepted in 2023-06-02,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMilitary field exercises are characterised by high volumes of exercise and prolonged periods of load carriage. Exercise can decrease circulating serum calcium and increase parathyroid hormone and bone resorption. These disturbances to calcium and bone metabolism can be attenuated with calcium supplementation immediately before exercise. This randomised crossover trial will investigate the effect of calcium supplementation on calcium and bone metabolism, and bone mineral balance, during load carriage exercise in women.MethodsThirty women (eumenorrheic or using the combined oral contraceptive pill, intrauterine system, or intrauterine device) will complete two experimental testing sessions either with, or without, a calcium supplement (1000 mg). Each experimental testing session will involve one 120 min session of load carriage exercise carrying 20 kg. Venous blood samples will be taken and analysed for biochemical markers of bone resorption and formation, calcium metabolism, and endocrine function. Urine will be collected pre- and post-load carriage to measure calcium isotopes for the calculation of bone calcium balance.DiscussionThe results from this study will help identify whether supplementing women with calcium during load carriage is protective of bone and calcium homeostasis.Trial registrationNCT04823156 (clinicaltrials.gov).

【 授权许可】

CC BY   
© Crown 2023

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