Surveillance and epidemiological characterization of human adenovirus infections among outpatient children with acute gastroenteritis during the COVID-19 epidemic in Shanghai, China

Virology Journal

Research

Menghua Xu¹  Lingfeng Cao¹  Ran Jia¹  Huaqing Zhong¹  Lijuan Lu¹  Liyun Su¹  Jin Xu²  Shuohua Duan³ 

[1] Department of Clinical Laboratory, Children’s Hospital of Fudan University, National Children’s Medical Center, 399 Wanyuan Road, 201102, Shanghai, China;Department of Clinical Laboratory, Children’s Hospital of Fudan University, National Children’s Medical Center, 399 Wanyuan Road, 201102, Shanghai, China;Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China;School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China;

关键词: Human adenovirus;    Children;    Outpatient;    Acute gastroenteritis;    COVID-19;   

DOI  :  10.1186/s12985-023-02105-z

 received in 2023-02-25, accepted in 2023-06-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHuman adenovirus (HAdV) has been recognized as one of the common enteric viruses associated with acute gastroenteritis (AGE) in children. The aim of this study was carried out to illustrate the epidemiological characterization of HAdV Infections among children younger than 15 years in Shanghai during COVID-19.MethodsDuring May 2020 and April 2022, 1048 fecal samples were collected from children ≤ 15 years diagnosed with AGE in the Children’s Hospital of Fudan University. HAdV was identified by PCR and sequenced with specific primers. All the obtained sequences were analyzed by MEGA (version 6.0). Demographic information and clinical features data were also collected and analyzed.ResultsIn total, 97 (9.3%, 97/1048) samples were detected to be HAdV during May 2020 and April 2022. We found an atypical upsurge in HAdV infection in the year 2021 after a major suppression in the year 2020. Approximately 84.5% (82/97) of HAdV-infected children were aged 0–60 months. Among the 97 HAdV-positive samples, only two species and five genotypes were detected. HAdV-F (88.7%, 86/97) was the most prevalent species and HAdV-F41 (87.6%, 85/97) was the most common genotype. Diarrhea, vomiting, and fever were the main clinical manifestations in children infected with HAdV. The children aged from 0 to 12 months showed simpler patterns of clinical presentation than those of children older than 13 months.ConclusionsOur findings described the epidemiological changes of HAdV infection in children with AGE during the COVID-19, which further underscored the importance of continuous surveillance of HAdV at both local and global scales.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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