The effect of neutrophil extracellular traps in venous thrombosis

Thrombosis Journal

Review

Zixiang Wang¹  Weiwei Li¹  Chen’guang Su¹  Zheng Liao¹  Jianli Wang¹  Jinlong Liu¹  Yinxuan Pei¹  Shijie Fu²  Zixin Li³ 

[1] Department of Hepatobiliary Surgery, Affiliated Hospital of Chengde Medical University, 067000, Chengde, Hebei Province, China;Department of Orthopedic, Affiliated Hospital of Chengde Medical University, 067000, Chengde, Hebei Province, China;Department of Pathology, Affiliated Hospital of Chengde Medical University, 067000, Chengde, Hebei Province, China;

关键词: Venous thrombosis;    Neutrophil;    Neutrophil extracellular traps;    Humans;   

DOI  :  10.1186/s12959-023-00512-4

 received in 2023-03-12, accepted in 2023-06-11,  发布年份 2023

来源: Springer

【 摘 要 】

Neutrophil extracellular traps (NETs) as special release products of neutrophils have received extensive attention. They are composed of decondensed chromatin and coated with nucleoproteins, including histones and some granulosa proteins. NETs can form a network structure to effectively capture and eliminate pathogens and prevent their spread. Not only that, recent studies have shown that NETs also play an important role in venous thrombosis. This review provides the most important updated evidence regarding the mechanism of NETs formation and the role of NETs in the process of venous thrombosis. The potential prophylactic and therapeutic value of NETs in venous thrombotic disease will also be discussed.

【 授权许可】

CC BY   
© The Author(s) 2023