Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Microbial Cell Factories

Review

Mohamed A. Goma¹  Mohamed A. Khodaira¹  Abdallah E. Emam¹  Amr H. Hashem¹  Mohamed S. Khader¹  Mohamed S. Attia¹  Mahmoud M. Fawzi¹  Amer M. Abdelaziz¹  Esalm K. Kandil¹  Ahmed S. Abdelrahman¹ 

[1] Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt;

关键词: Fungal endophytes;    Medicinal plants;    Antimicrobial activity;    Antioxidant activity;    Antiviral activity;    Anticancer activity;   

DOI  :  10.1186/s12934-023-02118-x

 received in 2022-12-08, accepted in 2023-05-22,  发布年份 2023

来源: Springer

【 摘 要 】

Human life has been significantly impacted by the creation and spread of novel species of antibiotic-resistant bacteria and virus strains that are difficult to manage. Scientists and researchers have recently been motivated to seek out alternatives and other sources of safe and ecologically friendly active chemicals that have a powerful and effective effect against a wide variety of pathogenic bacteria as a result of all these hazards and problems. In this review, endophytic fungi and their bioactive compounds and biomedical applications were discussed. Endophytes, a new category of microbial source that can produce a variety of biological components, have major values for study and broad prospects for development. Recently, endophytic fungi have received much attention as a source for new bioactive compounds. In addition, the variety of natural active compounds generated by endophytes is due to the close biological relationship between endophytes and their host plants. The bioactive compounds separated from endophytes are usually classified as steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones and enniatines. Moreover, this review discusses enhancement methods of secondary metabolites production by fungal endophytes which include optimization methods, co-culture method, chemical epigenetic modification and molecular-based approaches. Furthermore, this review deals with different medical applications of bioactive compounds such as antimicrobial, antiviral, antioxidant and anticancer activities in the last 3 years.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5