Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose

BMC Microbiology

Research

Jianlong Lao¹  Hehai Li¹  Ya Wang²  Jiahui Wang³  Dan Jia⁴  Youquan Li⁴  Jinming Wang⁵  Hong Yin⁵  Junlong Liu⁵  Jianxun Luo⁵  Guiquan Guan⁵ 

[1] Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, 524088, Zhanjiang, Guangdong, China;Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, 524088, Zhanjiang, Guangdong, China;College of Life Science and Engineering, Lanzhou University of Technology, 730050, Lanzhou, China;Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, 524088, Zhanjiang, Guangdong, China;College of Life Science and Engineering, Lanzhou University of Technology, 730050, Lanzhou, China;State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 730046, Lanzhou, China;Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, 524088, Zhanjiang, Guangdong, China;State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 730046, Lanzhou, China;State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 730046, Lanzhou, China;

关键词: Bifidobacterium longum;    Antioxidant;    Anti-aging;   

DOI  :  10.1186/s12866-023-02846-5

 received in 2023-01-07, accepted in 2023-04-02,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundProbiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose.ResultsT37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver.ConclusionsT37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.

【 授权许可】

CC BY   
© The Author(s) 2023

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