BioMedical Engineering OnLine | |
The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review | |
Review | |
Jingying Li1  Xuqian Liu1  Jian Wei1  Minhai Nie1  Miaoling Hu1  Jiana Chen1  Xiao Chen2  | |
[1] Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical University, 646000, Luzhuo, China;Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, 646000, Luzhou, China;Department of Stomatology Technology, School of Medical Technology, Sichuan College of Traditional Medicine, 621000, Mianyang, China;Department of Orthodontics, Mianyang Stomatological Hospital, 621000, Mianyang, China; | |
关键词: Decellularized vascular matrix; Extracellular matrix; Vascular graft; Vascular scaffold; | |
DOI : 10.1186/s12938-023-01120-z | |
received in 2023-01-31, accepted in 2023-05-28, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
Decellularized vascular matrix is a natural polymeric biomaterial that comes from arteries or veins which are removed the cellular contents by physical, chemical and enzymatic means, leaving only the cytoskeletal structure and extracellular matrix to achieve cell adhesion, proliferation and differentiation and creating a suitable microenvironment for their growth. In recent years, the decellularized vascular matrix has attracted much attention in the field of tissue repair and regenerative medicine due to its remarkable cytocompatibility, biodegradability and ability to induce tissue regeneration. Firstly, this review introduces its basic properties and preparation methods; then, it focuses on the application and research of composite scaffold materials based on decellularized vascular matrix in vascular tissue engineering in terms of current in vitro and in vivo studies, and briefly outlines its applications in other tissue engineering fields; finally, it looks into the advantages and drawbacks to be overcome in the application of decellularized vascular matrix materials. In conclusion, as a new bioactive material for building engineered tissue and repairing tissue defects, decellularized vascular matrix will be widely applied in prospect.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202309071422442ZK.pdf | 1191KB | download | |
41116_2023_37_Article_IEq275.gif | 1KB | Image | download |
Fig. 8 | 728KB | Image | download |
【 图 表 】
Fig. 8
41116_2023_37_Article_IEq275.gif
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