Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts

Biomaterials Research

Review

Huan-Jun Lu¹  Yoon Ki Joung²  Yu Ren³  Wei Zhang³  Mei-Xian Li⁴  Qian-Qi Wei⁵  Hui-Lin Mo⁶ 

[1] Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, 02792, Seoul, Republic of Korea;Department of Infectious Diseases, General Hospital of Tibet Military Command, Xizang, China;Division of Bio-Medical Science and Technology, University of Science and Technology (UST), 217 Gajeong-Ro, Yuseong-Gu, 34113, Daejeon, Republic of Korea;Fiber Composites for Safety and Protection, National and Local Joint Engineering Research Center of Technical, Nantong University, 226019, Nantong, China;School of Textile and Clothing, Nantong University, 226019, Nantong, China;Fiber Composites for Safety and Protection, National and Local Joint Engineering Research Center of Technical, Nantong University, 226019, Nantong, China;School of Textile and Clothing, Nantong University, 226019, Nantong, China;Department of Infectious Diseases, General Hospital of Tibet Military Command, Xizang, China;Institute of Special Environmental Medicine, Nantong University, 226019, Nantong, China;School of Textile and Clothing, Nantong University, 226019, Nantong, China;

关键词: Small-diameter vascular grafts;    Surface modification;    Cardiovascular diseases;    Biomimetics;    Tissue engineering;   

DOI  :  10.1186/s40824-023-00399-2

 received in 2023-02-15, accepted in 2023-05-21,  发布年份 2023

来源: Springer

【 摘 要 】

The arterial occlusive disease is one of the leading causes of cardiovascular diseases, often requiring revascularization. Lack of suitable small-diameter vascular grafts (SDVGs), infection, thrombosis, and intimal hyperplasia associated with synthetic vascular grafts lead to a low success rate of SDVGs (< 6 mm) transplantation in the clinical treatment of cardiovascular diseases. The development of fabrication technology along with vascular tissue engineering and regenerative medicine technology allows biological tissue-engineered vascular grafts to become living grafts, which can integrate, remodel, and repair the host vessels as well as respond to the surrounding mechanical and biochemical stimuli. Hence, they potentially alleviate the shortage of existing vascular grafts. This paper evaluates the current advanced fabrication technologies for SDVGs, including electrospinning, molding, 3D printing, decellularization, and so on. Various characteristics of synthetic polymers and surface modification methods are also introduced. In addition, it also provides interdisciplinary insights into the future of small-diameter prostheses and discusses vital factors and perspectives for developing such prostheses in clinical applications. We propose that the performance of SDVGs can be improved by integrating various technologies in the near future.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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