Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank

BMC Psychiatry

Research

Elleke Tissink¹  Alexey Shadrin²  Ole A. Andreassen²  Daniel Roelfs²  Oleksandr Frei²  Dag Alnaes³  Tobias Kaufmann⁴  Lars T. Westlye⁵  Dennis van der Meer⁶ 

[1] Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, The Netherlands;NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway;NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Bjørknes College, Oslo, Norway;NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany;German Center for Mental Health (DZPG), Tübingen, Germany;NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Psychology, University of Oslo, Oslo, Norway;NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway;School of Mental Health and Neuroscience, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands;

关键词: Computational psychiatry;    Mental health;    Brain connectivity;    Genetics;    Multivariate GWAS;   

DOI  :  10.1186/s12888-023-04905-7

 received in 2022-07-25, accepted in 2023-05-26,  发布年份 2023

来源: Springer

【 摘 要 】

Psychiatric disorders are complex clinical conditions with large heterogeneity and overlap in symptoms, genetic liability and brain imaging abnormalities. Building on a dimensional conceptualization of mental health, previous studies have reported genetic overlap between psychiatric disorders and population-level mental health, and between psychiatric disorders and brain functional connectivity. Here, in 30,701 participants aged 45–82 from the UK Biobank we map the genetic associations between self-reported mental health and resting-state fMRI-based measures of brain network function. Multivariate Omnibus Statistical Test revealed 10 genetic loci associated with population-level mental symptoms. Next, conjunctional FDR identified 23 shared genetic variants between these symptom profiles and fMRI-based brain network measures. Functional annotation implicated genes involved in brain structure and function, in particular related to synaptic processes such as axonal growth (e.g. NGFR and RHOA). These findings provide further genetic evidence of an association between brain function and mental health traits in the population.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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