Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis

Journal of Inflammation

Review

V. Smith¹  A. Salah²  D. Schonenberg-Meinema²  S. C. Bergkamp²  T. W. Kuijpers²  J. M. van den Berg²  S. Kamphuis³  M. J. Wahadat⁴  S. W. Tas⁵ 

[1] Department of Internal Medicine, Ghent University, Ghent, Belgium;Department of Rheumatology, Ghent University Hospital, Ghent, Belgium;Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Centre (IRC), Ghent, Belgium;Department of Paediatric Immunology, Rheumatology and Infectious Diseases, Emma Children’s Hospital, Amsterdam University Medical Centres (AUMC), University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands;Department of Paediatric Rheumatology, Sophia Children’s Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands;Department of Paediatric Rheumatology, Sophia Children’s Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands;Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands;Department of Rheumatology and Clinical Immunology, and Laboratory for Experimental Immunology, Amsterdam Rheumatology and Immunology Centre, Amsterdam University Medical Centres (AUMC), University of Amsterdam, Amsterdam, The Netherlands;

关键词: Endothelial cell;    Endothelial cell markers;    Systemic lupus erythematosus;    Premature atherosclerosis;    Cardiovascular disease;   

DOI  :  10.1186/s12950-023-00342-1

 received in 2022-10-05, accepted in 2023-04-28,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesTo perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic lupus erythematosus (SLE) in relation to disease activity, as EC dysregulation plays a major role in the development of premature atherosclerosis in SLE.MethodsSearch terms were entered into Embase, MEDLINE, Web of Science, Google Scholar and Cochrane. Inclusion criteria were 1) studies published after 2000 reporting measurements of EC markers in serum and/or plasma of SLE patients (diagnosed according to ACR/SLICC criteria), 2) English language peer reviewed articles, and 3) disease activity measurement. For meta-analysis calculations, the Meta-Essentials tool by Erasmus Research Institute and of Management (ERIM) was used. Only those EC markers, which were 1) reported in at least two articles and 2) reported a correlation coefficient (i.e. Spearman’s rank or Pearson’s) between the measured levels of the EC marker and disease activity were included. For meta-analyses,a fixed effect model was used.ResultsFrom 2133 hits, 123 eligible articles were selected. The identified SLE-related endothelial markers were involved in EC activation, EC apoptosis, disturbed angiogenesis, defective vascular tone control, immune dysregulation and coagulopathy. Meta-analyses of primarily cross-sectional studies showed significant associations between marker levels and disease activity for the following endothelial markers: Pentraxin-3, Thrombomodulin, VEGF, VCAM-1, ICAM-1, IP-10 and MCP-1. Dysregulated EC markers without associations with disease activity were: Angiopoeitin-2, vWF, P-Selectin, TWEAK and E-Selectin.ConclusionsWe provide a complete literature overview for dysregulated EC markers in SLE comprising a wide range of different EC functions. SLE-induced EC marker dysregulation was seen with, but also without, association with disease activity. This study provides some clarity in the eminent complex field of EC markers as biomarkers for SLE. Longitudinal data on EC markers in SLE are now needed to guide us more in unravelling the pathophysiology of premature atherosclerosis and cardiovascular events in SLE patients.

【 授权许可】

CC BY   
© The Author(s) 2023

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