The value of 18F-FDG PET/CT in the systemic evaluation of patients with Rosai–Dorfman disease: a retrospective study and literature review

Orphanet Journal of Rare Diseases

Research

Rongxi Wang¹  Zhaohui Zhu¹  Xinyu Lu¹ 

[1] Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, China;State Key Laboratory of Complex Severe and Rare Diseases, 100730, Beijing, China;

关键词: Rosai–Dorfman disease;    Lesion identification;    F-FDG PET/CT;    Non-Langerhans cell histiocytosis;   

DOI  :  10.1186/s13023-023-02711-8

 received in 2023-01-04, accepted in 2023-04-30,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundRosai–Dorfman disease (RDD) is a rare form of non-Langerhans cell histiocytic disease. The aim of this study was to review the characteristics of RDD using 18F-FDG PET/CT and determine its efficacy in the disease management.ResultsA total of 28 RDD patients underwent 33 18F-FDG PET/CT scans for systematic assessment and follow-up. The common involved sites included the lymph nodes (17, 60.7%), upper respiratory tract (11, 39.3%), and skin (9, 32.1%). Five patients had more lesions detected in PET/CT images than in CT and/or MRI, including inapparent nodules (n = 5) and bone destruction (n = 3). After thorough treatment evaluation using PET/CT, the treatment strategies of 14 patients (14/16, 87.5%) were changed. Five patients underwent PET/CT twice during follow-up and the SUVs were significantly decreased (15.3 ± 3.4 vs. 4.4 ± 1.0, p = 0.02), which demonstrated disease improvement.Conclusions18F-FDG PET/CT contributed to displaying the holistic characteristics of RDD, in particular during initial assessment, treatment strategy adjustment, or efficacy evaluation, and could compensate for some disadvantages of CT and MRI images.

【 授权许可】

CC BY   
© The Author(s) 2023

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