Predictors of caregiver adherence to administration of amodiaquine during delivery of seasonal malaria chemoprevention in Nigeria, Burkina Faso, Chad, and Togo

Malaria Journal

Research

Chibuzo Oguoma¹  Olabisi Ogunmola¹  Adaeze Aidenagbon¹  Taiwo Ibinaiye¹  Olusola Oresanya¹  Christian Rassi²  Sol Richardson³ 

[1] Malaria Consortium Nigeria, 33 Pope John Paul Street, Maitama, Abuja-FCT, Nigeria;Malaria Consortium UK, The Green House, 244-254 Cambridge Heath Road, E2 9DA, London, UK;Malaria Consortium UK, The Green House, 244-254 Cambridge Heath Road, E2 9DA, London, UK;Vanke School of Public Health, Tsinghua University, 100083, Beijing, China;

关键词: Malaria;    Seasonal malaria chemoprevention;    Community engagement;    Amodiaquine;   

DOI  :  10.1186/s12936-023-04576-5

 received in 2023-01-11, accepted in 2023-04-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMalaria is the leading cause of morbidity and mortality among infants and children under-five in sub-Saharan Africa. In the Sahel, seasonal malaria chemoprevention (SMC) is delivered door-to-door in monthly cycles. In each cycle, children are administered sulfadoxine–pyrimethamine (SP) plus amodiaquine (AQ) on Day 1 by community distributors, and AQ on Day 2 and Day 3 by caregivers. Non-adherence to AQ administration by caregivers has implications for emergence of antimalarial resistance.MethodsPredictors of non-adherence to administration of AQ on Day 2 and Day 3 among caregivers of children aged 3–59 months who had received Day 1 SP and AQ during the last 2020 SMC cycle (n = 12,730) were analysed using data from SMC coverage surveys in Nigeria, Burkina Faso and Togo, and fitting multivariate random-effects logistic regression models.ResultsPrevious adverse reaction to SMC medicines by eligible children (OR: 0.29, 95% CI 0.24–0.36, p < 0.001), awareness of the importance of administering Day 2 and Day 3 AQ (OR: 2.19, 95% CI 1.69–2.82, p < 0.001), caregiver age, and home visits to caregivers delivered by the Lead Mothers intervention in Nigeria (OR: 2.50, 95% CI 1.93–2.24, p < 0.001), were significantly associated with caregiver adherence to Day 2 and Day 3 AQ administration.ConclusionsIncreasing caregivers’ knowledge of SMC and interventions such as Lead Mothers have the potential to improve full adherence to AQ administration.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 9