Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation

BMC Cardiovascular Disorders

Research

Qiang Li¹  Dong Chang¹  Guiyang Li¹  Jincun Guo¹  Faguang Zhou¹  Binni Cai¹  Linlin Li¹  Jianghai Liu¹  Yingjian Deng¹  Qi Zheng² 

[1] Department of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen University, Xiamen, China;Department of Psychology, Xiamen Xianyue Hospital, Xiamen, China;

关键词: Atrial fibrillation;    Stroke;    Left atrial appendage thrombus;    Spontaneous echo contrast;    Neutrophil-lymphocyte ratio;    Monocyte to high-density lipoprotein ratio;   

DOI  :  10.1186/s12872-023-03270-3

 received in 2022-12-10, accepted in 2023-04-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe importance of inflammation in thrombosis is increasingly appreciated. Neutrophil-lymphocyte ratio (NLR) and monocyte to high-density lipoprotein ratio (MHR) are important indicators of systemic inflammation. This study aimed to investigate the associations between NLR and MHR with left atrial appendage thrombus (LAAT) and spontaneous echo contrast (SEC) in patients with non-valvular atrial fibrillation.MethodsThis retrospective, cross-sectional study enrolled 569 consecutive patients with non-valvular atrial fibrillation. Multivariable logistic regression analysis was used to investigate independent risk factors of LAAT/SEC. Receiver operating characteristic (ROC) curves were used to evaluate the specificity and sensitivity of NLR and MHR in predicting LAAT/SEC. Subgroup and Pearson correlation analyses were used to assess the correlations between NLR and MHR with the CHA2DS2-VASc score.ResultsMultivariate logistic regression analysis showed that NLR (OR: 1.49; 95%CI: 1.173–1.892) and MHR (OR: 2.951; 95%CI: 1.045–8.336) were independent risk factors for LAAT/SEC. The area under the ROC curve of NLR (0.639) and MHR (0.626) was similar to that of the CHADS2 score (0.660) and CHA2DS2-VASc score (0.637). Subgroup and Pearson correlation analyses showed significant but very weak associations between NLR (r = 0.139, P < 0.05) and MHR (r = 0.095, P < 0.05) with the CHA2DS2-VASc score.ConclusionGenerally, NLR and MHR are independent risk factors for predicting LAAT/SEC in patients with non-valvular atrial fibrillation.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 1