A rare case of pemphigus vulgaris disguised as a malignant gingival ulcer

BMC Oral Health

Case Report

Gui Liu¹  Jun Chen²  Ding Zhang²  Binjie Liu²  Hui Tang²  Yuqi Tang²  Wenjie Li³ 

[1] Department of Oral Pathology, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, 410008, Changsha, China;Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Central South University, 410008, Changsha, China;Department of Periodontics and Oral Medicine, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Central South University, 410008, Changsha, China;Department of Orthodontics, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, 410008, Changsha, China;

关键词: Pemphigus vulgaris (PV);    Oral mucosa;    Gingival ulcer;   

DOI  :  10.1186/s12903-023-02980-6

 received in 2022-12-09, accepted in 2023-04-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPemphigus vulgaris (PV) is a kind of rare and severe autoimmune bullous disease. In this case, the specificity of oral PV lies in the clinical manifestations of a single palatal ulcer, and no blisters were found in the oral mucosa. This case provides a powerful reference for dentists diagnosing and treating oral PV with atypical clinical presentations.Case presentationA 54 years old female patient presented with a non-healing palatal gingival ulcer for over three months. By histopathological H&E staining and the direct immunofluorescence (DIF) test, the final diagnosis was oral PV. After topical glucocorticoid therapy, the affected area was cured.ConclusionsIn patients with prolonged erosion of the skin or oral mucosa, even if complete blisters are not visible, the physician should consider autoimmune bullous diseases and pay attention to avoid diagnostic defects.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1