Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

Tropical Medicine and Health

Review

Mohamed A. El-Sweify¹  Amal A. El-Moamly² 

[1] Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt;Department of Medical Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt;

关键词: Malaria;    Plasmodium falciparum;    Vaccine;    Development;    History;    Challenges;    Approval;    RTS,S;    Implementation program;    Pre-erythrocytic vaccines;    Erythrocytic vaccines;    Blood-stage vaccines;    Transmission blocking vaccines;    Control;    Elimination;   

DOI  :  10.1186/s41182-023-00516-w

 received in 2022-10-03, accepted in 2023-04-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science. In 2021 the World Health Organization (WHO) approved the first malaria vaccine, RTS,S/AS01 vaccine (Mosquirix™), for widespread use.Main abstract bodyThis review highlights the history of development, and the different approaches and types of malaria vaccines, and the literature to date. It covers the developmental stages of RTS,S/AS01 and recommends steps for its deployment. The review explores other potential vaccine candidates and their status, and suggests options for their further development. It also recommends future roles for vaccines in eradicating malaria. Questions remain on how RTS,S vaccine will work in widespread use and how it can best be utilized to benefit vulnerable communities.ConclusionMalaria vaccines have been in development for almost 60 years. The RTS,S/AS01 vaccine has now been approved, but cannot be a stand-alone solution. Development should continue on promising candidates such as R21, PfSPZ and P. vivax vaccines. Multi-component vaccines may be a useful addition to other malaria control techniques in achieving eradication of malaria.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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