Postoperative serum interleukin-6 levels correlate with survival in stage I-III colorectal cancer

BMC Gastroenterology

Research

Zeshi Li¹  Tianhui Xue²  Bing Yan²  Qianwen Ye²  Shouhan Feng³  Mei Liu⁴ 

[1] Department of Critical Care Medicine, Hainan Hospital of PLA General Hospital, 572000, Sanya city of Hainan province, P.R. China;Department of Oncology, Hainan Hospital of PLA General Hospital, 572000, No. 80 of Jianglin Road, Haitang District of Sanya city, Hainan province, P.R. China;Department of Oncology, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, 313000, Huzhou city of Zhejiang Province, P.R. China;Department of Tumor Chemotherapy, Haikou People’s Hospital, 570208, Haikou city of Hainan province, P.R. China;

关键词: Colorectal cancer;    C-reactive protein;    Procalcitonin;    Interleukin-6;    Survival;   

DOI  :  10.1186/s12876-023-02800-9

 received in 2023-03-07, accepted in 2023-05-04,  发布年份 2023

来源: Springer

【 摘 要 】

AimsThe preoperative serum levels of inflammatory mediators, including C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6), have been demonstrated to be correlated with patient outcomes in colorectal cancer (CRC); however, the prognostic role of these levels has been less well-studied in postoperative settings.Materials and methodsA total of 122 stage I-III CRC patients were retrospectively enrolled. Serum levels of CRP, PCT and IL-6 were measured after surgery, and their prognostic value was evaluated. Kaplan-Meier analysis was used to determine the differences in disease-free survival (DFS) and overall survival (OS) between patients with different levels of these mediators, and the Cox proportional hazards model was used to estimate the risk factors.ResultsIn contrast to CRP and PCT, only the level of IL-6 was significant in predicting DFS (P = 0.01) but not OS (P = 0.07). A total of 66.39% (81/122) of patients were assigned to the low IL-6 group and no significant differences were found in the collected clinicopathological parameters among the low or high IL-6 subgroups. The level of IL-6 was negatively correlated with postoperative (1 w) (R=-0.24, P = 0.02) absolute lymphocyte counts. Patients with low levels of IL-6 had better DFS (log rank = 6.10, P = 0.01) but not OS (log rank = 2.28, P = 0.13). Finally, the level of IL-6 was an independent risk factor for DFS (HR: 1.81, 95% CI: 1.03–3.15, P = 0.04).ConclusionsCompared to CRP and PCT, the level of IL-6 was observed to be the only significant factor in predicting the prognosis of stage I-III CRC patients after surgery, and a low level of IL-6 was associated with good DFS.

【 授权许可】

CC BY   
© The Author(s) 2023

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