Trehalose versus carboxymethylcellulose oral spray for relieving radiation-induced xerostomia in head and neck cancer patients: a randomized controlled trial

BMC Oral Health

Research

Joao N. Ferreira¹  Khwanchanok Maison²  Thirayu Boonroung³  Jeerus Sucharitakul⁴  Pornpan Piboonratanakit⁵  Ganokon Urkasemsin⁶  Anussara Prayongrat⁷  Chawalit Lertbutsayanukul⁷  Kulpriya Pravinvongvuthi⁸  Anjalee Vacharaksa⁹ 

[1] Avatar Biotechnologies for Oral Health and Healthy Longevity Research Unit, Department of Research Affairs, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;Avatar Biotechnologies for Oral Health and Healthy Longevity Research Unit, Department of Research Affairs, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;Department of Preclinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Bangkok, Thailand;Dental Department, King Chulalongkorn Memorial Hospital, Bangkok, Thailand;Department of Biochemistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;Research Unit in Oral Diseases, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;Department of Preclinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Bangkok, Thailand;Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;Geriatric and Special Patients (International) Program, Faculty of Dentistry, Chulalongkorn University, 34 Henri-Dunant Road, Pathumwan, 10330, Bangkok, Thailand;Geriatric and Special Patients (International) Program, Faculty of Dentistry, Chulalongkorn University, 34 Henri-Dunant Road, Pathumwan, 10330, Bangkok, Thailand;Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;Excellent Center on Microbiology and Immunology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;

关键词: Head and neck cancer;    Radiotherapy;    Salivary gland;    Hyposalivation;    Xerostomia;    Trehalose;   

DOI  :  10.1186/s12903-023-02966-4

 received in 2022-11-17, accepted in 2023-04-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to investigate the effect of trehalose oral spray to relieve radiation-induced xerostomia on a randomized controlled trial (RCT).MethodsPrior to RCT, the effect of trehalose (5–20%) on the epithelial growth of fetal mouse salivary gland (SG) explants was evaluated to confirm if 10% trehalose exerted the best epithelial outcomes. Participants who completed radiotherapy for head and neck cancer (HNC) treatment were enrolled in a double-blind RCT, according to inclusion and exclusion criteria as per the CONSORT statement. The experimental group (n = 35) received 10% trehalose spray, while the control group (n = 35) received carboxymethylcellulose (CMC) spray to apply intra-orally 4 times/day for 14 days. Salivary pH and unstimulated salivary flow rate were recorded pre- and post-interventions. The Xerostomia-related Quality of Life scale (XeQoLs) was filled, and scores assessed post-interventions.ResultsIn the SG explant model, pro-acinar epithelial growth and mitosis was supported by 10% topical trehalose. As for RCT outcomes, salivary pH and unstimulated salivary flow rate were significantly improved after use of 10% trehalose spray when compared to CMC (p < 0.05). Participants reported an improvement of XeQoLs dimension scores after using trehalose or CMC oral sprays in terms of physical, pain/discomfort, and psychological dimensions (p < 0.05), but not social (p > 0.05). When comparing between CMC and trehalose sprays, XeQoLs total scores were not statistically different (p > 0.05).ConclusionsThe 10% trehalose spray improved salivary pH, unstimulated salivary flow rate, and the quality-of-life dimensions linked with physical, pain/discomfort, and psychological signs. The clinical efficacy of 10% trehalose spray was equivalent with CMC-based saliva substitutes for relieving radiation-induced xerostomia; therefore, trehalose may be suggested in alternative to CMC-based oral spray.(Thai Clinical Trials Registry; https://www.thaiclinicaltrials.org/ TCTR20190817004).

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2023_36_Article_IEq434.gif