PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h

European Journal of Hybrid Imaging

Original Article

Ulrika Bitzén¹  Berit Olsson²  Elin Trägårdh²  Erland Hvittfeldt²  Jenny Oddstig³  David Minarik⁴ 

[1] Department of Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Lund, Sweden;Department of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Carl Bertil Laurells gata 9, 205 02, Malmö, Sweden;Department of Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Malmö, Sweden;Department of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Carl Bertil Laurells gata 9, 205 02, Malmö, Sweden;Department of Medical Physics, Skåne University Hospital, Lund, Sweden;Department of Translational Medicine, Wallenberg Centre for Molecular Medicine, Lund University, Carl Bertil Laurells gata 9, 205 02, Malmö, Sweden;Department of Medical Physics, Skåne University Hospital, Malmö, Sweden;

关键词: [F]PSMA-1007;    Prostate cancer;    Uptake time;    PET/CT;    PSMA;   

DOI  :  10.1186/s41824-023-00167-4

 received in 2023-02-27, accepted in 2023-03-15,  发布年份 2023

来源: Springer

【 摘 要 】

Background[18F]PSMA-1007 is a prostate specific membrane antigen (PSMA) ligand for positron emission tomography (PET) imaging of prostate cancer. Current guidelines recommend imaging 90–120 min after injection but strong data about optimal timing is lacking. Our aim was to study whether imaging after 1 h and 2 h leads to a different number of detected lesions, with a specific focus on lesions that might lead to a change in treatment.Methods195 patients underwent PET with computed tomography imaging 1 and 2 h after injection of [18F]PSMA-1007. Three readers assessed the status of the prostate or prostate bed and suspected metastases. We analyzed the location and number of found metastases to determine N- and M-stage of patients. We also analyzed standardized uptake values (SUV) in lesions and in normal tissue.ResultsSignificantly more pelvic lymph nodes and bone metastases were found and higher N- and M-stages were seen after 2 h. In twelve patients (6.1%) two or three readers agreed on a higher N- or M-stage after 2 h. Conversely, in two patients (1.0%), two readers agreed on a higher stage at 1 h. SUVs in suspected malignant lesions and in normal tissues were higher at 2 h, but lower in the blood pool and urinary bladder.ConclusionsImaging at 2 h after injection of [18F]PSMA-1007 leads to more suspected metastases found than after 1 h, with higher staging in some patients and possible effect on patient treatment.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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