3D skeletal uptake of 18F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer

EJNMMI Research

Mattias Ohlsson¹  Reza Kaboteh²  May Sadik²  Nezar Hasani²  Lars Edenbrandt²  Poul F. Høilund-Carlsen³  Jane Simonsen³  Fredrik Kahl⁴  Olof Enqvist⁴  Sarah Lindgren Belal⁵  Elin Trägårdh⁵  Mads H. Poulsen⁶  Linus Svärm⁷ 

[1] Department of Astronomy and Theoretical Physics, Lund University;Department of Clinical Physiology, Sahlgrenska University Hospital;Department of Nuclear Medicine, Odense University Hospital;Department of Signals and Systems, Chalmers University of Technology;Department of Translational Medicine, Lund University;Department of Urology, Odense University Hospital;Eigenvision AB;

关键词: PET/CT;    Sodium fluoride;    Bone scan index;    Imaging biomarker;    Prostate cancer;   

DOI  :  10.1186/s13550-017-0264-5

来源: DOAJ

【 摘 要 】

Abstract Background Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer. Methods NaF PET/CT and bone scans were studied in 48 patients with prostate cancer. Automated segmentation of the thoracic and lumbar spines, sacrum, pelvis, ribs, scapulae, clavicles, and sternum were made in the CT images. Hotspots in the PET images were selected using both a manual and an automated method. The volume of each hotspot localized in the skeleton in the corresponding CT image was calculated. Two PET/CT indices, based on manual (manual PET index) and automatic segmenting using a threshold of SUV 15 (automated PET15 index), were calculated by dividing the sum of all hotspot volumes with the volume of all segmented bones. BSI values were obtained using a software for automated calculations. Results BSI, manual PET index, and automated PET15 index were all significantly associated with OS and concordance indices were 0.68, 0.69, and 0.70, respectively. The median BSI was 0.39 and patients with a BSI >0.39 had a significantly shorter median survival time than patients with a BSI <0.39 (2.3 years vs not reached after 5 years of follow-up [p = 0.01]). The median manual PET index was 0.53 and patients with a manual PET index >0.53 had a significantly shorter median survival time than patients with a manual PET index <0.53 (2.5 years vs not reached after 5 years of follow-up [p < 0.001]). The median automated PET15 index was 0.11 and patients with an automated PET15 index >0.11 had a significantly shorter median survival time than patients with an automated PET15 index <0.11 (2.3 years vs not reached after 5 years of follow-up [p < 0.001]). Conclusions PET/CT indices based on NaF PET/CT are correlated to BSI and significantly associated with overall survival in patients with prostate cancer.

【 授权许可】

Unknown