A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation

Journal of Nanobiotechnology

Research

Yanfeng Wu¹  Chenying Zeng¹  Lihua Li²  Guojian Li³  Zhongyu Xie³  Yunhui Zhang³  Huiyong Shen³  Peng Wang³  Jinteng Li³  Yucong Lin³  Guan Zheng³  Wenjie Liu³  Guiwen Ye³  Huatao Liu³  Xiaoshuai Peng³ 

[1] Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, P.R. China;Department of Applied Physics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, P.R. China;Future Technology Research Institute, South China Normal University, 55 Zhongshan Dadao, Tianhe District, Guangzhou, P.R. China;Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025# Shennan Road, Shenzhen, P.R. China;

关键词: MnFe2O4 nanoparticles;    Ankylosing spondylitis;    ROS scavenging;    Targeted therapy;    Nanomedicine;   

DOI  :  10.1186/s12951-023-01906-2

 received in 2022-12-23, accepted in 2023-04-19,  发布年份 2023

来源: Springer

【 摘 要 】

Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs) and TNF inhibitors, are limited by side effects, high costs and unclear inhibitory effects on heterotopic ossification. Herein, we developed manganese ferrite nanoparticles modified by the aptamer CH6 (CH6-MF NPs) that can efficiently scavenge ROS and actively deliver siRNA into hMSCs and osteoblasts in vivo for effective AS treatment. CH6-MF NPs loaded with BMP2 siRNA (CH6-MF-Si NPs) effectively suppressed abnormal osteogenic differentiation under inflammatory conditions in vitro. During their circulation and passive accumulation in inflamed joints in the Zap70mut mouse model, CH6-MF-Si NPs attenuated local inflammation and rescued heterotopic ossification in the entheses. Thus, CH6-MF NPs may be an effective inflammation reliever and osteoblast-specific delivery system, and CH6-MF-Si NPs have potential for the dual treatment of chronic inflammation and heterotopic ossification in AS.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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