Study on intestinal flora of acupoint catgut embedding intervention in female patients with abdominal obesity: study protocol for a randomized controlled trial

TMR Integrative Medicine

article

Qi-Fu Li¹  Jia-Lei Feng²  Xing-He Zhang¹  Li Li³  Xuan-Xiang Zeng¹  Si-Wen Zhao¹  Meng Kong¹  Yun-Qiu Zheng¹  Chong-Hui Xing⁴  Tai-Pin Guo¹ 

[1] School of Second Clinical medicine/The Second Affiliated Hospital of Yunnan University of Chinese Medicine;Institute for History of Medicine and Medical Literature, China Academy of Chinese Medical Sciences;The Third Affiliated Hospital, Yunnan University of Chinese Medicine;The sports Trauma Specialist Hospital of Yunnan Province

关键词: acupoint catgut embedding;    abdominal obesity;    intestinal flora;    16S rRNA;    female;    randomized controlled trial;   

DOI  :  10.53388/TMRIM202206010

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

Background: Obesity, as an epidemic public health issue in the world today, not only bringsa heavy medical burden to society but also seriously affects people’s quality of life. In thecontext of new evidence for the efficacy of acupoint catgut embedding (ACE) in abdominalobesity (AO), it is necessary to elucidate the mechanism of ACE for AO. The intestinal florais closely associated with obesity, and the study of its intestinal flora may provide evidenceto clarify the mechanism of obesity treatment by ACE. Methods: 75 participants will berecruited in this study, including 60 eligible female patients diagnosed with AO and 15healthy female participants. 60 female AO patients will be randomized to ACE group, shamACE group, and waiting list (WL) group in a ratio of 1:1:1. Patients in two ACE groups willreceive one ACE treatment per week for 12 consecutive weeks, and in the WL group will notreceive any treatment; only their data will be extracted. The primary outcome is the meanchange in body mass index. Secondary effects include waist circumference, body weight, thevisual analog score of appetite, and the Gastrointestinal Symptom Rating Scale.High-throughput 16S ribosomal ribonucleic acid gene sequencing will be used to detectintestinal flora in each group before and after the intervention. Conclusion: The results ofthis trial are expected to identify the critical intestinal flora causing AO and the targetintestinal flora of AO regulated by ACE, providing further theoretical support for ACE in theclinical treatment of obesity.

【 授权许可】

CC BY