Incidence of Diarrhea with Antibiotics and the Increase of Clostridia in Rabbits

Journal of Veterinary Medical Science

Yukiko HARA-KUDO¹  Yoshiaki NAGAOKA¹  Susumu KUMAGAI¹  Yoshiyuki MORISHITA¹  Fumiko KASUGA¹ 

关键词: antibiotic;    clostridium;    diarrhea;    intestinal flora;    rabbit;   

DOI  :  10.1292/jvms.58.12_1181

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Cited-By(3)Rabbits were treated with a single intravenous injection of various antibiotics. More than 40 per cent of the animals showed diarrhea after being treated with sulbactam/cefoperazone, cefmetazole, clindamycin, piperacillin or aspoxicillin. Clostridium difficile was isolated from sulbactam/cefoperazone-treated diarrheic rabbits, with their cecal contents showing positive reaction in a latex agglutination test for C. diffcile enterotoxin. However, 27 cefmetazole-induced diarrheic cases were not associated with C. difficile. Other enteropathogenic bacteria, such as Campylobacter spp., Bacillus cereus, enteropathogenic Escherichia coli, coagulase positive Staphylococcus aureus, Salmonella spp., Vibrio spp., Clostridium perfringens and Clostridium spiroforme, were not isolated from either of diarrheic rabbit. However, the counts of clostridia remarkably increased in the intestine of cefmetazole-associated diarrheic rabbits. This was ascribed to the overgrowth of Clostridium innocuum and Clostridium sporogenes. There were no remarkable differences in changes in other bacterial population between diarrheic and non-diarrheic rabbits.

【 授权许可】

Unknown