Target prediction of Chrysanthemum morifolium against hepatocellular carcinoma

TMR Integrative Medicine

article

Gang-Gang Li¹  Zhan-Fang Xie³  Yong-Jun Zhao¹  Wan-Gao Li¹  Guo-Feng Qi¹ 

[1] Department of Traditional Chinese Medicine, Anyang Vocational and Technical College;Basic Medical College, Hebei University of Chinese Medicine;Department of Pharmacy, Anyang Tumor Hospital

关键词: Chrysanthemum morifolium;    Hepatocellular carcinoma;    Network pharmacology;    Adrenergic receptoractivity;    Catecholamine binding;   

DOI  :  10.12032/TMRIM202105014

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

A novel computational system was used to decipher the targets and mechanisms of Chrysanthemum morifoliumagainst hepatocellular carcinoma. The putative target profile of Chrysanthemum morifolium against hepatocellularcarcinoma was identified from Traditional Chinese Medicine Systems Pharmacology and DrugBank. Next, identification of the protein-protein interaction network of Chrysanthemum morifolium against hepatocellularcarcinoma targets, and the identification of differentially expressed genes in hepatocellular carcinoma, relied ondata from the NCBI database. Finally, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were usedto analyze the common targets. Forty-eight active compounds in Chrysanthemum morifolium were identified byTraditional Chinese Medicine Systems Pharmacology and DrugBank, and 71 differentially expressed genes wereidentified in the GEO database. Further, 10 core target proteins were selected, including CYP1A1, ADRB2, ADRA1B, PGR, MAOB, SLC6A4, GABRA1, MAOA, NOS3 and PTGS2. These target genes were also found tobe associated with pathways involved in adrenergic receptor activity and catecholamine binding.

【 授权许可】

CC BY