Quantitative and qualitative comparison of neonatal screening plan for the identification of hypothyroid neonates between Nahavand and Kashmar cities in 2016–2017 (respectively in the west and east of Iran)

TMR Integrative Medicine

article

Maryam Soori¹  Sedigheh Soleymani²  Samira Tabaei³  Manoochehr Solgi⁴ 

[1] Department of Biochemistry, Islamic Azad University of Hamadan;Department of Biology, Damghan Branch, Islamic Azad University;3Diseases Research Center, Shiraz University of Medical Sciences;Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences

关键词: Neonatal hypothyroidism;    Screening;    Special filter paper;    Mental retardation;    Prevalence;    Iran;   

DOI  :  10.12032/TMRIM202004002

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

Background: Congenital hypothyroidism is the result of a reduction in thyroid hormone production or a decreasein the activity of thyroid hormone receptors and is one of the most preventable causes of mental retardation, deafness, and heart problems in the world. This study aimed to compare the prevalence of congenitalhypothyroidism between Nahavand in the west of Iran and Kashmar in the east of Iran during the years 2016–2017. Methods: This is a cross-sectional descriptive study on neonates born in April 2016 to March 2018 in two cities ofNahavand and Kashmar. A few drops of blood from a baby's heel in 3–5 birthdays on a special filter paper (S &S903) became blood samples from the pelvic floor were filtered and dried. The valuation of the samples wasperformed by the enzyme linked immunosorbent assay method by evaluating the thyroid stimulating hormone. Premature infants, underweight (less than 2,500 grams), a weight of over 4 kg, multiple births, or newbornsrequiring blood transfusions or any newborn needed to be retaken to the test after two weeks. Results: In the city ofNahavand, the incidence of neonatal hypothyroidism in the years 2016 and 2017 were 6.7 and 9.09 per 1,000 livebirths. And for the city of Kashmar, this number increased to 5.6 and 4.3 per 1,000 births in 2016 and 2017, respectively. The mean rate of participation in the screening program in the first 3–5 days of birth in Nahavandduring two years was 2016 and 2017 to 78.7% and in Kashmar about 94%, which indicates the higher participationof Kashmar. In the city of Nahavand, 64.6% of cases of hypothyroidism reported in boys' neonates and 51.5% ofmale children in the Kashmar city. Conclusion: The results of our survey indicates that the prevalence ofhypothyroidism is high in both Kashmar in eastern Iran and Nahavand in western Iran. Especially in Nahavand cityof western Iran, where the prevalence of hypothyroidism is higher than global and internal statistics. Furthersurveys are required to elucidate the role of iodine deficiency and family marriage in the hereafter.

【 授权许可】

CC BY