TMR Integrative Medicine | |
Application of diffusion kurtosis imaging technology in evaluating early mild traumatic brain injury | |
article | |
Zhi-jie Zhang1  Wei Liu1  Guo-shi Lv1  Zheng Pan1  Xiao-min Liu1  Bo Wang2  | |
[1] Medical Imaging Department of the Hospital of PLA 81st Group Army;Radiology Department of Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences | |
关键词: Mild traumatic brain injury; Magnetic resonance imaging; Diffusion kurtosis imaging; | |
DOI : 10.12032/TMRIM202004011 | |
学科分类:医学(综合) | |
来源: TMR publishing group | |
【 摘 要 】
Objective To explore the value of magnetic resonance diffusion kurtosis imaging in diagnosing early tiny changesof brain tissue after mild traumatic brain injury. Methods A total of 22 patients with mild traumatic brain injury(study group) and 20 healthy subjects (control group) were enrolled in this study, and diffusion kurtosis imagingmagnetic resonance scanning was employed in all subjects. fractional anisotropy, fractional anisotropy of kurtosis, mean kurtosis, axial kurtosis and radial kurtosis of diffusion kurtosis imaging parameters in the genu of corpuscallosum, splenium corporis callosi, internal capsule, thalamus, putamen, cortex of frontal lobe, temporal lobe andparietal lobe at control group, the injured side and the mirror regions were measured, and the results were comparedbetween the two groups. The receiver operating characteristic curve was used to evaluate the ability of differentparameters in diagnosing mild traumatic brain injury. Results Compared with the control group, in the study groupfractional anisotropy values of bilateral genu of corpus callosum, splenium corporis callosi, internal capsule andthalamus were significantly reduced, and fractional anisotropy of kurtosis values of bilateral thalamus and putamenwere significantly reduced, and the differences were statistically significant (P<0.05). Compared with the controlgroup, in the study group mean kurtosis and axial kurtosis values of bilateral genu of corpus callosum, posteriorlimb of Internal capsule, thalamus, putamen and cortex of temporal lobe were significantly reduced, while radialkurtosis values in the genu of corpus callosum, thalamus, cortex of frontal lobe, temporal lobe at the injured sidewere increased, and the differences were statistically significant (P < 0.05). Conclusion DKI techniques cansensitively detect the early tiny pathologic changes of cerebral tissue in mild traumatic brain injury patients, whichprovide more imaging evidence for the clinical early diagnosis treatment and prognosis.
【 授权许可】
CC BY
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