Application of magnetic resonance diffusion kurtosis imaging for distinguishing histopathologic subtypes and grades of rectal carcinoma

Cancer Imaging

Xinyue Yang¹  Baolan Lu²  Ziqiang Wen²  Yiyan Liu²  Bingqi Shen²  Yan Chen²  Shenping Yu² 

[1] Department of Radiology, Southern Medical University Zhujiang Hospital;Department of Radiology, Sun Yat-sen University First Affiliated Hospital;

关键词: Rectal cancer;    Magnetic resonance imaging;    Diffusion kurtosis imaging;    Mucinous carcinoma;    Imaging biomarker;   

DOI  :  10.1186/s40644-019-0192-x

来源: DOAJ

【 摘 要 】

Abstract Background To evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) for distinguishing different histopathological subtypes and grades of rectal carcinoma and to compare DKI with conventional diffusion-weighted imaging (DWI). Methods This prospective study involved 132 patients with rectal carcinoma, comprising 116 with adenocarcinoma not otherwise specified (AC) and 16 with mucinous carcinoma (MC). High spatial resolution magnetic resonance (MR) and DKI sequences (b values of 0, 600, 1000, 1500 and 2000 s/mm2) were performed for pretreatment evaluation. The mean kurtosis (MK) and mean diffusivity (MD) from DKI and the apparent diffusion coefficient (ADC) from DWI were measured by two experienced radiologists. The Mann-Whitney U test was used to evaluate different histopathological subtypes and grades. Receiver operating characteristic (ROC) curve analyses were performed to compare the diagnostic ability of different quantitative parameters. Results The MD and ADC values were significantly higher for MC than for AC (1.94 ± 0.51 vs. 1.33 ± 0.02 and 1.26 ± 0.64 vs. 0.92 ± 0.01, respectively; P < 0.001). The MK values were significantly lower for MC than for AC (0.66 ± 0.02 vs. 0.93 ± 0.09, P < 0.001). The MK and MD values demonstrated higher sensitivity (94%, both) and specificity (96, 93%, respectively) than the ADC values. However, all the parameters derived from both DKI and DWI showed no significant differences between different histological grades. Conclusions DKI is a more valuable imaging biomarker than conventional DWI for differentiating MC from AC. However, it is still debatable whether DKI is useful for distinguishing different histological grades.

【 授权许可】

Unknown