Pathogenesis and treatment status of adenomyosis complicated with infertility

TMR Integrative Medicine

article

Hua Wang¹  Chun-Hua Cao¹  Yan Chen¹  Saili Wang¹  Qin Wang¹ 

[1] Taizhou Hospital of Traditional Chinese Medicine, Affiliated to Nanjing University of Traditional Chinese Medicine

关键词: Adenomyosis;    Infertility;    Pathogenesis;    Treatment;    Endometrium;   

DOI  :  10.12032/TMRIM201903004

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

Adenomyosis (AD) refers to the endometrium (including glands and stroma) into myometriumgrowth of pathological changes, with the delay of women's childbearing age, the patients withAD-associated infertility increased significantly. Although scholars disagreed about the effectof AD on infertility, more and more evidence showed that AD was closely related to thestructural and functional defects of the eutopic endometrium and myometrial junctional zone(MJZ), which may lead to embryo implantation failure and infertility. With the rapiddevelopment of imaging technology, the accuracy of diagnose AD has been enhanced, moreand more infertility patients were diagnosed with AD. At the same time, a series of pathogenichypothesis have been proposed to explain the relationship between AD. In addition, AD mayinfluence the patient’s reproductive function by affecting sperm transport, embryoimplantation, altering uterine peristalsis, influencing the structure and function ofendometrium, and changing the intrauterine environment. At present, the treatment ofAD-associated infertility is similar to the treatment of AD. The commonly used treatmentmethods include drug therapy, conservative operative treatment, drug combination surgery,and Chinese medicine treatment and so on. The clinical and experimental studies of ADcomplicated with infertility and its possible pathogenesis and treatment in recent years arereviewed in this article.

【 授权许可】

CC BY