Drugs in Context | |
Granulocyte and monocyte/macrophage apheresis in paediatric patients with ulcerative colitis: a case series in Spain | |
article | |
Javier Martin de Carpi1  | |
[1] Unit for Integral Care of Paediatric Inflammatory Bowel Disease, Gastroenterology, Hepatology and Nutrition Department, Hospital Sant Joan de Déu | |
关键词: adolescent; azathioprine; child; corticosteroids; granulocyte-monocyte apheresis; leukocytapheresis; paediatric ulcerative colitis; tumour necrosis factor inhibitors; | |
DOI : 10.7573/dic.2021-10-6 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: C S F Medical Communications Ltd. | |
【 摘 要 】
Paediatric ulcerative colitis (UC) can cause malnutrition and growth retardation but its treatment can be limited by the potential adverse events of corticosteroids and anti-TNF agents in children. However, adsorptive granulocyte monocyte/macrophage apheresis (GMA) using Adacolumn® reduces intestinal inflammation through multiple immunomodulatory effects. This case series shows the safety and efficacy of GMA in paediatric UC, illustrating several GMA uses: in chronically active UC, for corticosteroid reduction in steroid-dependent UC, in UC with secondary loss of response to anti-TNF therapy, as bridge therapy in UC with failure of anti-TNF therapy, and to substitute toxic drug treatments.
【 授权许可】
CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202307150001704ZK.pdf | 476KB | download |