The adverse effect profile of oral azathioprine in pediatric atopic dermatitis, and recommendations for monitoring

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:72

Article

Fuggle, Nicholas R.^1,2  Bragoli, Walter¹  Mahto, Anjali³  Glover, Mary¹  Martinez, Anna E.¹  Kinsler, Veronica A.^1,4 

[1] Great Ormond St Hosp Children Natl Hlth Serv NHS, Pediat Dermatol Dept, London, England

[2] St George Hosp, Dept Med, London, England

[3] Royal Free Hosp, Dept Dermatol, London NW3 2QG, England

[4] UCL, Inst Child Hlth, London, England

关键词: atopic dermatitis;    azathioprine;    child;    eczema;    guidelines;    monitoring;    pediatric;    safety;    systemic;    therapy;   

DOI  :  10.1016/j.jaad.2014.08.048

来源: Elsevier

【 摘 要 】

Background: Azathioprine is efficacious in the treatment of severe childhood atopic dermatitis; however, robust data on adverse effects in this population are lacking. Objective: We sought to assess adverse effects of azathioprine treatment in a pediatric atopic dermatitis cohort, and make recommendations for monitoring based on these data. Methods: Blood test results for all 82 children prescribed oral azathioprine for atopic dermatitis in our department between 2010 and 2012 were collated prospectively, and clinical notes were reviewed retrospectively. Results: Mean age at commencing azathioprine was 8.3 years (SEM 0.4). Mean maximum doses were 2.4 mg/kg (SEM 0.1) and 1.5 mg/kg (SEM 0.1) for normal and reduced serum thiopurine-S-methyltransferase levels, respectively. Adverse effects on blood indices occurred in 34 of 82 patients (41%), with pronounced effects in 18 of 82 (22%) after a median time of 0.4 years. Two patients stopped therapy as a result of abnormal blood indices. Clinical adverse effects occurred in 16 of 82 (20%), two resulting in cessation of therapy. Incidence of adverse effects was unaffected by age, sex, thiopurine-S-methyltransferase level, and drug dose on multivariate regression. Limitations: Comparison with other studies is limited by varying definitions of adverse effects. Conclusion: Oral azathioprine was associated with few pronounced adverse effects for the duration of use and dosage in this cohort. Recommendations for monitoring are made.

【 授权许可】

Free