Efficacy of Dual Lung Cancer Screening by Chest X-Ray and SputumCytology Using Johns Hopkins Lung Project Data

Journal of Biometrics & Biostatistics

article

Seongho Kim¹  Diane Erwin²  Dongfeng Wu¹ 

[1] Dept of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville;Information Management Services, Inc.

关键词: Cytology;    X-ray;    Sojourn time;    Sensitivity;    Transitionprobability;    Lung cancer screening;   

DOI  :  10.4172/2155-6180.1000139

来源: Hilaris Publisher

【 摘 要 】

We investigate the efficacy of the dual-screening, annual chest X-ray and 4-monthly sputum cytology, for lungcancer detection using the Johns Hopkins Lung Project (JHLP) data. An advanced statistical approach to testing thedependency of dual diagnostic tests, chest X-ray and sputum cytology is applied for lung cancer detection. To achievethis, the screening sensitivities of X-ray only, cytology only, and dual-screening, the overall transition probability, thesojourn time, and the mean lead time were estimated from JHLP data. A derivative-free global optimization method,Particle Swarm Optimization (PSO), was further employed in the procedure to avoid being stuck at a local optimum orthe boundary. Our analysis shows that the overall sensitivity of lung cancer screening is 85.34% with chest X-ray of79.93% and 4-monthly sputum cytology of 26.98%, resulting in a small correlation coefficient of -0.0039, which is notsignificantly different from zero. As a result, the dual procedure improves the overall screening sensitivity up to ~5% inlung cancer detection.

【 授权许可】

Unknown