Selective Syntheses of Coumarin and Benzofuran Derivatives Using Phenols and α-Methoxy-β-ketoesters

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Ryo Miyata¹  Takashi Shigeta¹  Shigenori Kumazawa¹  Masahiro Egi¹ 

[1] Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka

关键词: coumarin;    benzofuran;    selective syntheses;    phenol;    α-methoxy-β-ketoester;    α-methoxyacetophenone;   

DOI  :  10.1055/s-0042-1751408

学科分类：精神健康和精神病学

来源: Thieme

【 摘 要 】

Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols and α-methoxy-β-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans are formed in the presence of water. In the synthetic process of benzofurans, α-methoxy-β-ketoesters are converted into α-methoxyacetophenones, and the methoxy group is an important element in the intermolecular annulation.

【 授权许可】

CC BY|CC BY-NC-ND