Organocatalytic Synthesis of γ-Amino Acid Precursors via Masked Acetaldehyde under Micellar Catalysis

SynOpen

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Maria Edith Casacchia¹  Giuliana Giorgianni¹  Elena Allegritti¹  Luisa Giansanti¹  Armando Carlone¹  Fabio Pesciaioli¹ 

[1] Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell’Aquila;IUSS Scuola Universitaria Superiore di Pavia;INSTM

关键词: micellar catalysis;    aminocatalysis;    asymmetric synthesis;    γ-amino acids;    green chemistry;   

DOI  :  10.1055/a-1996-8940

学科分类：精神健康和精神病学

来源: Thieme

【 摘 要 】

The development of micellar catalysis offers a sustainable alternative to organic solvents, and represents an environmental milestone in organic synthesis. Here, the first Michael addition of masked acetaldehyde under neutral, cationic and anionic micellar catalysis is reported, affording the products in high yields and enantiomeric excess, despite the use of water as solvent.

【 授权许可】

CC BY|CC BY-NC-ND