Facile Synthesis of 2H-Benzo[h]Chromenes via an Arylamine-Catalyzed Mannich Cyclization Cascade Reaction

Molecules

Wei Wang¹  Fanxun Zeng¹  Peng Ji¹  Feng Gao¹  Yueteng Zhang¹  Xiang Meng¹ 

[1] Departments of Pharmacology and Toxicology and Chemistry and Biochemistry, and BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA;

关键词: aminocatalysis;    cascade reaction;    chromenes;    organocatalysis;    quinone methide;   

DOI  :  10.3390/molecules26123617

来源: DOAJ

【 摘 要 】

A simple arylamine-catalyzed Mannich-cyclization cascade reaction was developed for facile synthesis of substituted 2H-benzo[h]chromenes. The notable feature of the process included the efficient generation of ortho-quinone methides (o-QMs) catalyzed by a simple aniline. The mild reaction conditions allowed for a broad spectrum of 1- and 2-naphthols and trans-cinnamaldehydes to engage in the cascade sequence with high efficiency.

【 授权许可】

Unknown