Recent Progress on the [3+2] Cycloaddition Route for the Synthesis of All-Carbon Quaternary Stereocentres

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Ani Deepthi¹  Maneesh Mohan¹  Meenakshy C. Balachandran¹ 

[1] Department of Chemistry, University of Kerala, Kariavattom campus

关键词: all-carbon;    quaternary;    stereocentres;    [3+2] cycloaddition;    cyclization;   

DOI  :  10.1055/a-1947-3351

学科分类：精神健康和精神病学

来源: Thieme

【 摘 要 】

Construction of all-carbon quaternary centres is an important task in organic synthesis. In spite of the challenges associated with Csp3–Csp3 bond construction in a sterically constrained environment, significant advances have been made in this area. Among the latter, both catalytic and noncatalytic [3+2] cycloaddition approaches have gained wide attention recently. This short review summarizes the [3+2] cycloaddition reactions reported during the period 2016–2022 for the synthesis of molecules possessing one or more all-carbon quaternary stereocentres.

【 授权许可】

CC BY|CC BY-NC-ND