Silent myelin-weighted magnetic resonance imaging

Wellcome Open Research

article

Tobias C. Wood¹  Nikou L. Damestani¹  Andrew J. Lawrence²  Emil Ljungberg¹  Gareth J. Barker¹  Ana Beatriz Solana³  Florian Wiesinger¹  Steven C.R. Williams¹ 

[1]Department of Neuroimaging, King's College London

[2]Department of Psychological Medicine, King's College London

[3]ASL Europe, GE Healthcare

关键词: ihMT;    Silent MRI;    Myelin;    ZTE;    RUFIS;   

DOI  :  10.12688/wellcomeopenres.15845.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast.Methods: A Magnetization Transfer preparation module was incorporated into a radial Zero Echo-Time sequence. Repeatability of the ihMT ratio and inverse ihMT ratio were assessed in a cohort of healthy subjects. We also investigated how head orientation affects ihMT across subjects, as a previous study in a single subject suggests this as a potential confound.Results: We demonstrated that ihMT ratios comparable to existing, acoustically loud, implementations could be obtained with the silent sequence. We observed a small but significant effect of head orientation on inverse ihMTR.Conclusions: Silent ihMT imaging is a comparable alternative to conventional, noisy, alternatives. For all future ihMT studies we recommend careful positioning of the subject within the scanner.

【 授权许可】

CC BY