Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review

Wellcome Open Research

article

Agnes M. Mutua¹  Reagan M. Mogire¹  Alison M. Elliott⁴  Thomas N. Williams¹  Emily L. Webb⁸  Amina Abubakar¹  Sarah H. Atkinson¹ 

[1] KEMRI-Wellcome Trust Research Programme;Department of Public Health, School of Human and Health Sciences, Pwani University;Open University, KEMRI-Wellcome Trust Research Programme - Accredited Research Centre;Medical Research Council / Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit;Department of Clinical Research, London School of Hygiene and Tropical Medicine;Department of Medicine, Imperial College London;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford;MRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine;Department of Psychiatry, University of Oxford;Institute for Human Development, Aga Khan University;Department of Paediatrics, University of Oxford

关键词: Vitamin D deficiency;    neurobehavioural outcomes;    brain development;    children;    cognitive;    motor;    language;    development;   

DOI  :  10.12688/wellcomeopenres.15730.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Introduction: Vitamin D plays an important role in brain development in experimental studies; however, the effect of vitamin D deficiency on child development remains inadequately characterized. We aimed to estimate the effects of vitamin D deficiency on neurobehavioural outcomes in children up to 18 years of age.Methods: We searched PubMed, EMBASE, PsycINFO, Scopus, Cochrane Library, Web of Science and Open Grey for published studies up to 10th January 2020. We included all studies that assessed the effects of maternal or child vitamin D status or vitamin D supplementation on neurobehavioural outcomes in children. Study findings were synthesized qualitatively as the high level of heterogeneity in study populations and methodologies precluded a quantitative meta-analysis.Results: Our search identified 5,633 studies, of which 31 studies with 31,375 participants from 18 countries were included in the systematic review. Of the studies identified, one was a randomised controlled trial (RCT) of vitamin D supplementation in children, while 30 were observational. The RCT (n=55) reported a beneficial effect of supplementation with lower doses compared to higher doses of vitamin D on motor development. Twelve mother-child studies (n=17,136) and five studies in children (n=1,091) reported an association between low maternal or child 25-hydroxyvitamin D levels and impaired neurobehavioural outcomes in children, while 15 mother-child studies (n=20,778) and eight studies in children (n=7,496) reported no association.Conclusions: Although animal studies point to an effect of vitamin D deficiency on brain development, there are few studies on the effects of vitamin D deficiency on neurobehavioural outcomes in children and their findings are inconsistent. There is a need for well-conducted, adequately powered studies to further determine these effects in children.Registration: PROSPERO IDCRD42018087619; registered on 15 February 2018.

【 授权许可】

CC BY