Research trends and hotspots of mesenchymal stromal cells in intervertebral disc degeneration: a scientometric analysis

EFORT Open Reviews

article

Minghe Yao¹  Tingkui Wu²  Beiyu Wang² 

[1]West China School of Medicine, Sichuan University

[2]Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University

关键词: mesenchymal stromal cell;    intervertebral disc degeneration;    scientometric analysis;   

DOI  :  10.1530/EOR-22-0083

学科分类：神经科学

来源: The British Editorial Society of Bone & Joint Surgery

【 摘 要 】

Mesenchymal stromal cells (MSCs) are important potential candidates for regenerative therapy for intervertebral disc degeneration (IDD). This scientometric study aimed to summarize the main research trends, identify current research hotspots, and measure the networks of the contributors and their scientific productivity. A total of 1102 publications regarding MSC in IDD were recognized from January 2000 to April 2022. The number of records every year followed an overall uptrend with fluctuations. The main trend of research demonstrated the practice of gradually applying MSC-based therapy to IDD with the assistance of advances in biomaterials and IDD pathology. A recent focus on MSC-derived exosomes and notochordal cells was detected. The basic studies in this field were mainly contributed to by Japan, the USA, and European countries, while China dominated in the number of recent publications. Tokai University with Daisuke Sakai was the most productive contributor. Cell biology, tissue engineering, and biomaterials were the categories with deep engagement in research of this field.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND