Study of Peripheral Microcirculation Assessed by Nailfold Video-Capillaroscopy and Association with Markers of Endothelial Dysfunction and Inflammation in Rheumatoid Arthritis

Mediterranean Journal of Rheumatology

article

Elena Angeloudi¹  Eleni Bekiari¹  Eleni Pagkopoulou²  Panagiota Anyfanti²  Michael Doumas³  Alexandros Garyfallos²  Theodoros Dimitroulas² 

[1] Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki;Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki;Second Propaedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki

关键词: microcirculation;    nailfold videocapillaroscopy;    rheumatoid arthritis;    endothelial dysfunction;    atherosclerosis;    inflammation markers;   

DOI  :  10.31138/mjr.33.3.375

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease that primarily affects synovial joints and is associated with increased cardiovascular (CV) mortality and morbidity. This association is only partially attributed to the presence of classic CV disease risk factors, and is strongly associated with characteristics of disease itself namely systemic chronic inflammation and autoimmune activation. Growing evidence suggests that microvascular endothelial dysfunction contributes to the initiation and progression of vascular disease. Nailfold capillaroscopy is a non-invasive method that evaluates the morphology and the structure of nailfold capillaries. Extension of this method is the Nailfold Videocapillaroscopy (NVC), which provides the possibility of combining functional and anatomical study of peripheral microcirculation. The present cross-sectional study aims to evaluate using NVC the peripheral microcirculation in adult patients with RA and investigate the associations between structural and functional indices of digital capillaries with markers of atherosclerosis.

【 授权许可】

CC BY-NC