Role of Mesenchymal Stem Cells on Tonsillar Hypertrophy: An Unexplored Enigma

Journal of Nepal Medical Association

article

Apar Pokharel¹  DharmagatBhattarai² 

[1] Department of Otorhinolaryngology and Head and Neck Surgery, College of Medical Sciences;Department of Pediatrics, Postgraduate Institute of Medical Education and Research

关键词: interleukin-4;    mesenchymal stem cell;    tonsillar hypertrophy.;   

DOI  :  10.31729/jnma.7470

学科分类：社会科学、人文和艺术（综合）

来源: Nepal Medical Association since

【 摘 要 】

Tonsillar or adenoid hypertrophy is a common childhood finding which can cause significant health problems like respiratory infections and sleep apnea. Though normal growth of children is also attributed to such enlargement, infection, environmental pollutants, allergens, and gastroesophageal reflux are proposed triggering factors for tonsillar hypertrophy. While tonsilar enlargement in adults is more associated with malignancy and chronic infections like the human immunodeficiency virus, the immunology of childhood adenotonsillar hypertrophy is less understood. We postulate that upon stimulation, mesenchymal stem cells are found to reduce the secretion of interferon-gamma but increase the secretion of interleukin-4 from activated T cells. Both of these factors inhibit apoptosis in the tonsillar tissue leading to its hypertrophy. Under the umbrella of evidence, it implicates the role of mesenchymal stem cells in tonsillar hypertrophy. However, further longitudinal large studies are needed to validate the proposition.

【 授权许可】

CC BY