The Effect of Rheum ribes Root (Rhubarb) on Menopausal Hot Flashes: a Randomized Double-Blind, Placebo-Controlled Trial

Research Journal of Pharmacognosy

article

Najmeh Bagheriani¹  Mohsen Bahrami³  Mohammad Kamalinejad⁴  Zahra Rampisheh⁵  Maryam Kashanian⁶  Elham Akhtari¹ 

[1]Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences

[2]Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences

[3]Persian Medicine Clinic, Tehran University Healthcare Center

[4]Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences

[5]Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Department of Community and Family Medicine, School of Medicine, Iran University of Medical Sciences

[6]Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences

关键词: Herbal medicine;    Hot flash;    menopause;    Rheum ribes;   

DOI  :  10.22127/rjp.2022.342450.1896

学科分类：环境科学（综合）

来源: Iranian Society of Pharmacognosy

【 摘 要 】

Background and objectives: Hot flashes are one of the most predominant complaints of menopauseamong women. The main treatment is hormone replacement therapy, which has side effects. Therefore,the use of plants with phytoestrogen has been suggested as an adjunctive treatment. This study aimedto estimate the efficacy of processed rhubarb (Rheum ribes L.) on hot flashes in postmenopausalwomen. Methods: This double-blind placebo-controlled trial was performed on postmenopausalwomen who were referred to public health centers at Iran University of Medical Sciences. Ninetypostmenopausal women aged over 45 years with menopausal hot flashes were randomly assigned totwo groups. The treatment group received 500 mg of encapsulated processed R. ribes twice a day foreight weeks, and the control group received placebo (starch powder) in the same manner. Data werecollected using Blatt–Kupperman index at the start of the study, fourth and eighth weeks after theintervention. Descriptive and analytic statistics were used to analyze the data. Results: A total of 74patients completed the study (39 participants in the intervention group and 35 in the control group).The results showed that R. ribes significantly decreased the mean of flashing in Blatt–Kuppermanindex four and eight weeks post-intervention (p<0.001). Rheum ribes showed no serious adverseeffects. Conclusion: The findings of this study propose that treatment with R. ribes may beconsidered an adjunctive treatment for hot flashes in postmenopausal women.

【 授权许可】

CC BY-NC